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Contrave can be a combination in the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, which might make them far better and safer. Combo-pilling may be the newest fad or also the newest ahead under scrutiny and thus it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular is the fact that at the time of right now there are not any long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug may also raise blood pressure levels and heartrate, and really should not be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must 't be used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. "This is the first drug I'm alert to that targets the appetite and reward centres inside brain," he said.